Hiroshi Saito, Ph.D.

Bio / Education: 

Graduate School (PhD)
University of Tokyo, Japan

Research Fellow 
Baylor College of Medicine, Houston, Texas

PubMed Publications: 

  • Starr, M.E.;Takahashi, H.;Okamura, D.;Zwischenberger, B.A.;Mrazek, A.A.;Ueda, J.;Stromberg, A.J.;Evers, M.B.;Esmon, C.T.;Saito, H. "Increased coagulation and suppressed generation of activated protein C in aged mice during intra-abdominal sepsis." Am J Physiol Heart Circ Physiol 308, 2 (2015): H83-91. [PubMed Link] | [ Full text ]
  • Starr, M.E.;Takahashi, H.;Okamura, D.;Zwischenberger, B.A.;Mrazek, A.A.;Ueda, J.;Stromberg, A.J.;Evers, B.M.;Esmon, C.T.;Saito, H. "Increased coagulation and suppressed generation of activated protein C in aged mice during intra-abdominal sepsis." American journal of physiology. Heart and circulatory physiology 308, 2 (2015): H83-91. [PubMed Link] | [ Full text ]
  • Starr, M.E.;Saito, M.;Evers, M.B.;Saito, H. "Age-Associated Increase in Cytokine Production During Systemic Inflammation-II: The Role of IL-1β in Age-Dependent IL-6 Upregulation in Adipose Tissue." J Gerontol A Biol Sci Med Sci (2014): [PubMed Link] | [ Full text ]
  • Starr, M.E.;Saito, M.;Evers, B.M.;Saito, H. "Age-Associated Increase in Cytokine Production During Systemic Inflammation-II: The Role of IL-1β in Age-Dependent IL-6 Upregulation in Adipose Tissue." The journals of gerontology. Series A, Biological sciences and medical sciences (2014): [PubMed Link] | [ Full text ]
  • Shinozaki, S.;Chang, K.;Sakai, M.;Shimizu, N.;Yamada, M.;Tanaka, T.;Nakazawa, H.;Ichinose, F.;Yamada, Y.;Ishigami, A.;Ito, H.;Ouchi, Y.;Starr, M.E.;Saito, H.;Shimokado, K.;Stamler, J.S.;Kaneki, M. "Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65." Science signaling 7, 351 (2014): ra106. [PubMed Link] | [ Full text ]
  • Starr, M.E.;Saito, H. "Sepsis in old age: review of human and animal studies." Aging Dis 5, 2 (2014): 126-36. [PubMed Link] | [ Full text ]
  • Starr, M.E.;Saito, H. "Sepsis in old age: review of human and animal studies." Aging and disease 5, 2 (2014): 126-36. [PubMed Link] |
  • Starr, M.E.;Steele, A.M.;Saito, M.;Hacker, B.J.;Evers, M.B.;Saito, H. "A new cecal slurry preparation protocol with improved long-term reproducibility for animal models of sepsis." PLoS One 9, 12 (2014): e115705. [PubMed Link] | [ Full text ]
  • Shinozaki, S.;Chang, K.;Sakai, M.;Shimizu, N.;Yamada, M.;Tanaka, T.;Nakazawa, H.;Ichinose, F.;Yamada, Y.;Ishigami, A.;Ito, H.;Ouchi, Y.;Starr, M.E.;Saito, H.;Shimokado, K.;Stamler, J.S.;Kaneki, M. "Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65." Sci Signal 7, 351 (2014): ra106. [PubMed Link] | [ Full text ]
  • Starr, M.E.;Steele, A.M.;Saito, M.;Hacker, B.J.;Evers, B.M.;Saito, H. "A new cecal slurry preparation protocol with improved long-term reproducibility for animal models of sepsis." PloS one 9, 12 (2014): e115705. [PubMed Link] | [ Full text ]
  • Tucsek, Z.;Gautam, T.;Sonntag, W.E.;Toth, P.;Saito, H.;Salomao, R.;Szabo, C.;Csiszar, A.;Ungvari, Z. "Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients." J Gerontol A Biol Sci Med Sci 68, 6 (2013): 652-60. [PubMed Link] | [ Full text ]
  • Starr, M.E.;Hu, Y.;Stromberg, A.J.;Carmical, J.R.;Wood, T.G.;Evers, B.M.;Saito, H. "Gene expression profile of mouse white adipose tissue during inflammatory stress: age-dependent upregulation of major procoagulant factors." Aging cell 12, 2 (2013): 194-206. [PubMed Link] | [ Full text ]
  • Mustain, C.W.;Starr, M.E.;Valentino, J.D.;Cohen, D.A.;Okamura, D.;Wang, C.;Evers, M.B.;Saito, H. "Inflammatory cytokine gene expression in mesenteric adipose tissue during acute experimental colitis." PLoS One 8, 12 (2013): e83693. [PubMed Link] |
  • Mustain, W.C.;Starr, M.E.;Valentino, J.D.;Cohen, D.A.;Okamura, D.;Wang, C.;Evers, B.M.;Saito, H. "Inflammatory cytokine gene expression in mesenteric adipose tissue during acute experimental colitis." PloS one 8, 12 (2013): e83693. [PubMed Link] | [ Full text ]
  • Okamura, D.;Starr, M.E.;Lee, E.Y.;Stromberg, A.J.;Evers, B.M.;Saito, H. "Age-dependent vulnerability to experimental acute pancreatitis is associated with increased systemic inflammation and thrombosis." Aging cell 11, 5 (2012): 760-9. [PubMed Link] | [ Full text ]
  • Starr, M.E.;Saito, H. "Age-related increase in food spilling by laboratory mice may lead to significant overestimation of actual food consumption: implications for studies on dietary restriction, metabolism, and dose calculations." The journals of gerontology. Series A, Biological sciences and medical sciences 67, 10 (2012): 1043-8. [PubMed Link] | [ Full text ]
  • Wang, X.;Mandal, A.K.;Saito, H.;Pulliam, J.F.;Lee, E.Y.;Ke, Z.J.;Lu, J.;Ding, S.;Li, L.;Shelton, B.J.;Tucker, T.;Evers, B.M.;Zhang, Z.;Shi, X. "Arsenic and chromium in drinking water promote tumorigenesis in a mouse colitis-associated colorectal cancer model and the potential mechanism is ROS-mediated Wnt/β-catenin signaling pathway." Toxicology and applied pharmacology 262, 1 (2012): 11-21. [PubMed Link] | [ Full text ]
  • Takahashi, H.;Okamura, D.;Starr, M.E.;Saito, H.;Evers, B.M. "Age-dependent reduction of the PI3K regulatory subunit p85α suppresses pancreatic acinar cell proliferation." Aging cell 11, 2 (2012): 305-14. [PubMed Link] | [ Full text ]
  • Starr, M.E.;Ueda, J.;Yamamoto, S.;Evers, B.M.;Saito, H. "The effects of aging on pulmonary oxidative damage, protein nitration, and extracellular superoxide dismutase down-regulation during systemic inflammation." Free radical biology & medicine 50, 2 (2011): 371-80. [PubMed Link] | [ Full text ]
  • Starr, M.E.;Ueda, J.;Takahashi, H.;Weiler, H.;Esmon, C.T.;Evers, B.M.;Saito, H. "Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin." Blood 115, 23 (2010): 4886-93. [PubMed Link] | [ Full text ]
  • Starr, M.E.;Evers, B.M.;Saito, H. "Age-associated increase in cytokine production during systemic inflammation: adipose tissue as a major source of IL-6." The journals of gerontology. Series A, Biological sciences and medical sciences 64, 7 (2009): 723-30. [PubMed Link] | [ Full text ]
  • Ueda, J.;Starr, M.E.;Takahashi, H.;Du, J.;Chang, L.Y.;Crapo, J.D.;Evers, B.M.;Saito, H. "Decreased pulmonary extracellular superoxide dismutase during systemic inflammation." Free radical biology & medicine 45, 6 (2008): 897-904. [PubMed Link] | [ Full text ]
  • Watanabe, H.;Saito, H.;Ueda, J.;Evers, B.M. "Regulation of pancreatic duct cell differentiation by phosphatidylinositol-3 kinase." Biochemical and biophysical research communications 370, 1 (2008): 33-7. [PubMed Link] | [ Full text ]
  • Watanabe, H.;Saito, H.;Nishimura, H.;Ueda, J.;Evers, B.M. "Activation of phosphatidylinositol-3 kinase regulates pancreatic duodenal homeobox-1 in duct cells during pancreatic regeneration." Pancreas 36, 2 (2008): 153-9. [PubMed Link] | [ Full text ]
  • Watanabe, H.;Saito, H.;Rychahou, P.G.;Uchida, T.;Evers, B.M. "Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation." Gastroenterology 128, 5 (2005): 1391-404. [PubMed Link] | [ Full text ]
  • Izumi, T.;Brown, D.B.;Naidu, C.V.;Bhakat, K.K.;Macinnes, M.A.;Saito, H.;Chen, D.J.;Mitra, S. "Two essential but distinct functions of the mammalian abasic endonuclease." Proceedings of the National Academy of Sciences of the United States of America 102, 16 (2005): 5739-43. [PubMed Link] | [ Full text ]
  • Ueda, J.;Saito, H.;Watanabe, H.;Evers, B.M. "Novel and quantitative DNA dot-blotting method for assessment of in vivo proliferation." American journal of physiology. Gastrointestinal and liver physiology 288, 4 (2005): G842-7. [PubMed Link] | [ Full text ]
  • Hashimoto, K.;Ethridge, R.T.;Saito, H.;Rajaraman, S.;Evers, B.M. "The PPARgamma ligand, 15d-PGJ2, attenuates the severity of cerulein-induced acute pancreatitis." Pancreas 27, 1 (2003): 58-66. [PubMed Link] | [ Full text ]
  • Saito, H.;Sherwood, E.R.;Varma, T.K.;Evers, B.M. "Effects of aging on mortality, hypothermia, and cytokine induction in mice with endotoxemia or sepsis." Mechanisms of ageing and development 124, 10-12 (2003): 1047-58. [PubMed Link] | [ Full text ]