The UK Department of Surgery is composed of 11 divisions:
- Acute Care Surgery, Trauma, and Surgical Critical Care
- Cardiothoracic Surgery
- Colon and Rectal Surgery
- General, Endocrine, and Metabolic Surgery (GEMS)
- Health Outcomes & Optimal Patient Services (HOOPS)
- Pediatric Surgery
- Plastic Surgery
- Research Division
- Surgical Oncology
- Vascular and Endovascular
Faculty in a number of these specialties also play a role in multidisciplinary centers, which draw together faculty and staff from several departments to enhance patient care and research. For example, Surgery's Section of Transplantation, which handles kidney, liver, and pancreas transplants, and the Division of Cardiothoracic Surgery play essential roles in UK Hospital's Transplant Center. Other research and clinical centers with whom the UK Department of Surgery's faculty play significant roles include The Saha Cardiovascular Research Center, Markey Cancer Center, and Gill Heart Institute.
The Cardiothoracic Surgery, General Surgery, and Plastic Surgery provide accredited residency and fellowship programs to train new specialists in the most advanced facets of surgical care. In the Center for Advanced Training & Simulation (CATS), faculty who specialize in laparoscopic surgery collaborate with engineers and specialists from other disciplines to improve instruments and training techniques.