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Roberto Gedaly, MD
rgeda2's picture
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  • rgeda2@email.uky.edu
  • 859-323-4661
  • K 301 Kentucky Clinic, 740 S. Limestone, 40536-0284
Position(s): 
Professor of Surgery
Chief of Transplant Section
Affiliation(s): 
Surgery
Other Affiliation(s): 
Surgery/Transplant
Bio / Education: 

Medical School
Universidad Central de Venezuela, Caracas, Venezuela

Residency
Hospital General del Oeste, Caracas, Venezuela
Hospital Universitario de Caracas, Caracas, Venezuela

Fellowship
Beth Israel Deaconess Medical Center, Boston, MA
Jackson Memorial Hospital, University of Miami
Methodist University Hospital, University of Tennessee

Board Certification
Surgery, Transplantation

Surgical Interests
Hepatobiliary and transplantation
Liver and GI transplantation

PubMed Publications: 
  • El-Husseini, A.;Saleh, S.;Hamad, O.;Mei, X.;Castellanos, AL ;Davenport, DL ;Gedaly, R.;Sawaya, BP "Outcome of Patients With Small Vessel Vasculitis After Renal Transplantation: National Database Analysis." Transplantation direct 4, 3 (2018): e350. [PubMed Link] |
  • Shah, MB ;Vilchez, V.;Goble, A.;Daily, MF ;Berger, JC ;Gedaly, R.;DuBay, DA "Socioeconomic factors as predictors of organ donation." The Journal of surgical research 221, (2018): 88-94. [PubMed Link] | [ Full text ]
  • Ruiz, J.;Dugan, A.;Davenport, DL ;Gedaly, R. "Blood transfusion is a critical determinant of resource utilization and total hospital cost in liver transplantation." Clinical transplantation 32, 2 (2018): [PubMed Link] | [ Full text ]
  • Lui, SK ;Garcia, CR ;Mei, X.;Gedaly, R. "Re-transplantation for Hepatic Artery Thrombosis: A National Perspective." World journal of surgery (2018): [PubMed Link] | [ Full text ]
  • Vilchez, V.;Turcios, L.;Butterfield, DA ;Mitov, MI ;Coquillard, CL ;Brandon, JA ;Cornea, V.;Gedaly, R.;Marti, F. "Evidence of the immunomodulatory role of dual PI3K/mTOR inhibitors in transplantation: an experimental study in mice." Transplant international : official journal of the European Society for Organ Transplantation 30, 10 (2017): 1061-1074. [PubMed Link] | [ Full text ]
  • García, C.;Acosta, LF ;Gedaly, R. "Expanding the boundaries of Milan." Hepatobiliary surgery and nutrition 6, 5 (2017): 329-331. [PubMed Link] | [ Full text ]
  • Acosta, LF ;Garcia, CR ;Dugan, A.;Marti, F.;Davenport, D.;Gedaly, R. "Impact of super obesity on perioperative outcomes after hepatectomy: The weight of the risk." Surgery 162, 5 (2017): 1026-1031. [PubMed Link] | [ Full text ]
  • El-Husseini, A.;Aghil, A.;Ramírez, J.;Sawaya, B.;Rajagopalan, N.;Baz, M.;Mei, X.;Davenport, DL ;Gedaly, R. "Outcome of kidney transplant in primary, repeat, and kidney-after-nonrenal solid-organ transplantation: 15-year analysis of recent UNOS database." Clinical transplantation 31, 11 (2017): [PubMed Link] | [ Full text ]
  • Atienza, LG ;Berger, J.;Mei, X.;Shah, MB ;Daily, MF ;Grigorian, A.;Gedaly, R. "Liver transplantation for fibrolamellar hepatocellular carcinoma: A national perspective." Journal of surgical oncology 115, 3 (2017): 319-323. [PubMed Link] | [ Full text ]
  • Huaman, MA ;Vilchez, V.;Mei, X.;Shah, MB ;Daily, MF ;Berger, J.;Gedaly, R. "Decreased graft survival in liver transplant recipients of donors with positive blood cultures: a review of the United Network for Organ Sharing dataset." Transplant international : official journal of the European Society for Organ Transplantation 30, 6 (2017): 558-565. [PubMed Link] | [ Full text ]
  • Turcios, L.;Vilchez, V.;Acosta, LF ;Poyil, P.;Butterfield, DA ;Mitov, M.;Marti, F.;Gedaly, R. "Sorafenib and FH535 in combination act synergistically on hepatocellular carcinoma by targeting cell bioenergetics and mitochondrial function." Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 49, 6 (2017): 697-704. [PubMed Link] | [ Full text ]
  • Garcia, CR ;Acosta, LF ;Mei, X.;Berger, J.;Shah, MB ;Daily, MF ;Grigorian, A.;Gedaly, R. "Liver Transplantation for the Treatment of Complicated Iatrogenic Biliary Injuries: A National Review from the UNOS Data Set." Transplantation 101, 12 (2017): 2883-2887. [PubMed Link] | [ Full text ]
  • Alvarez, J.;Mei, X.;Daily, M.;Shah, M.;Grigorian, A.;Berger, J.;Marti, F.;Gedaly, R. "Tipping the Scales: Liver Transplant Outcomes of the Super Obese." Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20, 9 (2016): 1628-35. [PubMed Link] | [ Full text ]
  • Jackson, N.;Dugan, A.;Davenport, D.;Daily, M.;Shah, M.;Berger, J.;Gedaly, R. "Risk factors for increased resource utilization and critical care complications in patients undergoing hepaticojejunostomy for biliary injuries." HPB : the official journal of the International Hepato Pancreato Biliary Association 18, 9 (2016): 712-7. [PubMed Link] | [ Full text ]
  • Kanthawar, P.;Mei, X.;Daily, MF ;Chandarana, J.;Shah, M.;Berger, J.;Castellanos, AL ;Marti, F.;Gedaly, R. "Kidney Transplant Outcomes in the Super Obese: A National Study From the UNOS Dataset." World journal of surgery 40, 11 (2016): 2808-2815. [PubMed Link] | [ Full text ]
  • Crittenden, NE ;Buchanan, LA ;Pinkston, CM ;Cave, B.;Barve, A.;Marsano, L.;McClain, CJ ;Jones, CM ;Marvin, MR ;Davis, EG ;Kuns-Adkins, CB ;Gedaly, R.;Brock, G.;Shah, MB ;Rosenau, J.;Cave, MC "Simeprevir and sofosbuvir with or without ribavirin to treat recurrent genotype 1 hepatitis C virus infection after orthotopic liver transplantation." Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 22, 5 (2016): 635-43. [PubMed Link] | [ Full text ]
  • Carias, S.;Castellanos, AL ;Vilchez, V.;Nair, R.;Dela Cruz, AC ;Watkins, J.;Barrett, T.;Trushar, P.;Esser, K.;Gedaly, R. "Nonalcoholic steatohepatitis is strongly associated with sarcopenic obesity in patients with cirrhosis undergoing liver transplant evaluation." Journal of gastroenterology and hepatology 31, 3 (2016): 628-33. [PubMed Link] | [ Full text ]
  • Coquillard, C.;Berger, J.;Daily, M.;Shah, M.;Mei, X.;Marti, F.;Gedaly, R. "Combined liver-kidney transplantation for polycystic liver and kidney disease: analysis from the United Network for Organ Sharing dataset." Liver international : official journal of the International Association for the Study of the Liver 36, 7 (2016): 1018-25. [PubMed Link] | [ Full text ]
  • Vilchez, V.;Turcios, L.;Marti, F.;Gedaly, R. "Targeting Wnt/β-catenin pathway in hepatocellular carcinoma treatment." World journal of gastroenterology 22, 2 (2016): 823-32. [PubMed Link] | [ Full text ]
  • Vilchez, V.;Shah, MB ;Daily, MF ;Pena, L.;Tzeng, CW ;Davenport, D.;Hosein, PJ ;Gedaly, R.;Maynard, E. "Long-term outcome of patients undergoing liver transplantation for mixed hepatocellular carcinoma and cholangiocarcinoma: an analysis of the UNOS database." HPB : the official journal of the International Hepato Pancreato Biliary Association 18, 1 (2016): 29-34. [PubMed Link] | [ Full text ]
  • Vilchez, V.;Gedaly, R. "Liver transplantation for the treatment of neuroendocrine liver metastases." Best practice & research. Clinical endocrinology & metabolism 30, 1 (2016): 141-7. [PubMed Link] | [ Full text ]
  • Vilchez, V.;Turcios, L.;Zaytseva, Y.;Stewart, R.;Lee, EY ;Maynard, E.;Shah, MB ;Daily, MF ;Tzeng, CW ;Davenport, D.;Castellanos, AL ;Krohmer, S.;Hosein, PJ ;Evers, BM ;Gedaly, R. "Cancer stem cell marker expression alone and in combination with microvascular invasion predicts poor prognosis in patients undergoing transplantation for hepatocellular carcinoma." American journal of surgery 212, 2 (2016): 238-45. [PubMed Link] | [ Full text ]
  • Huaman, MA ;Vilchez, V.;Mei, X.;Davenport, D.;Gedaly, R. "Donor positive blood culture is associated with delayed graft function in kidney transplant recipients: a propensity score analysis of the UNOS database." Clinical transplantation 30, 4 (2016): 415-20. [PubMed Link] | [ Full text ]
  • Kril, LM ;Vilchez, V.;Jiang, J.;Turcios, L.;Chen, C.;Sviripa, VM ;Zhang, W.;Liu, C.;Spear, B.;Watt, DS ;Gedaly, R. "N-Aryl benzenesulfonamide inhibitors of 3H -thymidine incorporation and β-catenin signaling in human hepatocyte-derived Huh-7 carcinoma cells." Bioorganic & medicinal chemistry letters 25, 18 (2015): 3897-9. [PubMed Link] | [ Full text ]
  • Langone, A.;Steinberg, SM ;Gedaly, R.;Chan, LK ;Shah, T.;Sethi, KD ;Nigro, V.;Morgan, JC ;STRATO, Investigators. "Switching STudy of Kidney TRansplant PAtients with Tremor to LCP-TacrO (STRATO): an open-label, multicenter, prospective phase 3b study." Clinical transplantation 29, 9 (2015): 796-805. [PubMed Link] | [ Full text ]
  • Dela Cruz, AC ;Vilchez, V.;Kim, S.;Barnes, B.;Ravinuthala, A.;Zanni, A.;Galuppo, R.;Sourianarayanane, A.;Patel, T.;Maynard, E.;Shah, MB ;Daily, MF ;Uhl, T.;Esser, K.;Gedaly, R. "A prospective analysis of factors associated with decreased physical activity in patients with cirrhosis undergoing transplant evaluation." Clinical transplantation 29, 11 (2015): 958-64. [PubMed Link] | [ Full text ]
  • Hance, JM ;Harris, JW ;Neltner, J.;Vilchez, V.;Tzeng, CW ;Maynard, E.;Gedaly, R.;Shah, MB "Hepatobiliary mucinous cystadenoma resulting in biliary obstruction." The American surgeon 81, 6 (2015): E238-9. [PubMed Link] | [ Full text ]
  • Kim, S.;Maynard, EC ;Shah, MB ;Daily, MF ;Tzeng, CW ;Davenport, DL ;Gedaly, R. "Risk factors for 30-day readmissions after hepatectomy: analysis of 2444 patients from the ACS-NSQIP database." Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 19, 2 (2015): 266-71. [PubMed Link] | [ Full text ]
  • Sundar Alagusundaramoorthy, S.;Vilchez, V.;Zanni, A.;Sourianarayanane, A.;Maynard, E.;Shah, M.;Daily, MF ;Pena, LR ;Gedaly, R. "Role of transplantation in the treatment of benign solid tumors of the liver: a review of the United Network of Organ Sharing data set." JAMA surgery 150, 4 (2015): 337-42. [PubMed Link] | [ Full text ]
  • Alagusundaramoorthy, SS ;Gedaly, R. "Role of surgery and transplantation in the treatment of hepatic metastases from neuroendocrine tumor." World journal of gastroenterology 20, 39 (2014): 14348-58. [PubMed Link] | [ Full text ]
  • Williams, AM ;Seay, TM ;Hundley, JC ;Gedaly, R. "Direct intranodal lymphangiography for recurrent chylous ascites following liver-kidney transplantation." Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20, 10 (2014): 1275-6. [PubMed Link] | [ Full text ]
  • Galuppo, R.;Ramaiah, D.;Ponte, OM ;Gedaly, R. "Molecular therapies in hepatocellular carcinoma: what can we target?" Digestive diseases and sciences 59, 8 (2014): 1688-97. [PubMed Link] | [ Full text ]
  • Galuppo, R.;Maynard, E.;Shah, M.;Daily, MF ;Chen, C.;Spear, BT ;Gedaly, R. "Synergistic inhibition of HCC and liver cancer stem cell proliferation by targeting RAS/RAF/MAPK and WNT/β-catenin pathways." Anticancer research 34, 4 (2014): 1709-13. [PubMed Link] | [ Full text ]
  • Gedaly, R.;Galuppo, R.;Daily, MF ;Shah, M.;Maynard, E.;Chen, C.;Zhang, X.;Esser, KA ;Cohen, DA ;Evers, BM ;Jiang, J.;Spear, BT "Targeting the Wnt/β-catenin signaling pathway in liver cancer stem cells and hepatocellular carcinoma cell lines with FH535." PloS one 9, 6 (2014): e99272. [PubMed Link] | [ Full text ]
  • Gedaly, R.;Galuppo, R.;Musgrave, Y.;Angulo, P.;Hundley, J.;Shah, M.;Daily, MF ;Chen, C.;Cohen, DA ;Spear, BT ;Evers, BM "PKI-587 and sorafenib alone and in combination on inhibition of liver cancer stem cell proliferation." The Journal of surgical research 185, 1 (2013): 225-30. [PubMed Link] | [ Full text ]
  • Gedaly, R.;Guidry, P.;Davenport, D.;Daily, M.;Ronsenau, J.;Shah, M.;Cooper, MA ;Hundley, J. "Peri-operative challenges and long-term outcomes in liver transplantation for polycystic liver disease." HPB : the official journal of the International Hepato Pancreato Biliary Association 15, 4 (2013): 302-6. [PubMed Link] | [ Full text ]
  • Galuppo, R.;McCall, A.;Gedaly, R. "The role of bridging therapy in hepatocellular carcinoma." International journal of hepatology 2013, (2013): 419302. [PubMed Link] | [ Full text ]
  • Gedaly, R.;Angulo, P.;Chen, C.;Creasy, KT ;Spear, BT ;Hundley, J.;Daily, MF ;Shah, M.;Evers, BM "The role of PI3K/mTOR inhibition in combination with sorafenib in hepatocellular carcinoma treatment." Anticancer research 32, 7 (2012): 2531-6. [PubMed Link] | [ Full text ]
  • Moreno Elola-Olaso, A.;Davenport, DL ;Hundley, JC ;Daily, MF ;Gedaly, R. "Predictors of surgical site infection after liver resection: a multicentre analysis using National Surgical Quality Improvement Program data." HPB : the official journal of the International Hepato Pancreato Biliary Association 14, 2 (2012): 136-41. [PubMed Link] | [ Full text ]
  • Gedaly, R.;Angulo, P.;Hundley, J.;Daily, MF ;Chen, C.;Evers, BM "PKI-587 and sorafenib targeting PI3K/AKT/mTOR and Ras/Raf/MAPK pathways synergistically inhibit HCC cell proliferation." The Journal of surgical research 176, 2 (2012): 542-8. [PubMed Link] | [ Full text ]
  • Gedaly, R.;Daily, MF ;Davenport, D.;McHugh, PP ;Koch, A.;Angulo, P.;Hundley, JC "Liver transplantation for the treatment of liver metastases from neuroendocrine tumors: an analysis of the UNOS database." Archives of surgery (Chicago, Ill. : 1960) 146, 8 (2011): 953-8. [PubMed Link] | [ Full text ]
  • McHugh, PP ;Shah, SH ;Johnston, TD ;Gedaly, R.;Ranjan, D. "Predicting dry weight in patients with ascites and liver cirrhosis using computed tomography imaging." Hepato-gastroenterology 57, 99-100 (2010): 591-7. [PubMed Link] |
  • McHugh, PP ;Gilbert, J.;Vera, S.;Koch, A.;Ranjan, D.;Gedaly, R. "Alpha-fetoprotein and tumour size are associated with microvascular invasion in explanted livers of patients undergoing transplantation with hepatocellular carcinoma." HPB : the official journal of the International Hepato Pancreato Biliary Association 12, 1 (2010): 56-61. [PubMed Link] | [ Full text ]
  • Gedaly, R.;Angulo, P.;Hundley, J.;Daily, MF ;Chen, C.;Koch, A.;Evers, BM "PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathways." Anticancer research 30, 12 (2010): 4951-8. [PubMed Link] | [ Full text ]
  • Chen, C.;Johnston, TD ;Jeon, H.;Gedaly, R.;McHugh, P.;Ranjan, D. "Cyclosporin A up-regulates and activates protein kinase C-zeta in EBV-infected and EBV-transformed human B-cells." The Journal of surgical research 153, 1 (2009): 156-61. [PubMed Link] | [ Full text ]
  • McHugh, PP ;Bietz, GJ ;Jeon, H.;Johnston, TD ;Gedaly, R.;Ranjan, D. "Transjugular intrahepatic portosystemic shunt to keep vein open." Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 15, 5 (2009): 558-60. [PubMed Link] | [ Full text ]
  • Gedaly, R.;McHugh, PP ;Johnston, TD ;Jeon, H.;Ranjan, D.;Davenport, DL "Obesity, diabetes, and smoking are important determinants of resource utilization in liver resection: a multicenter analysis of 1029 patients." Annals of surgery 249, 3 (2009): 414-9. [PubMed Link] | [ Full text ]
  • Chen, C.;Johnston, TD ;Jeon, H.;Gedaly, R.;McHugh, P.;Ranjan, D. "Cyclosporine promotes epstein-barr virus-infected human B-cell transformation assayed by three correlated assay methods." Transplantation proceedings 41, 1 (2009): 366-70. [PubMed Link] | [ Full text ]
  • Chen, C.;Johnston, TD ;Jeon, H.;Gedaly, R.;McHugh, PP ;Burke, TG ;Ranjan, D. "An in vitro study of liposomal curcumin: stability, toxicity and biological activity in human lymphocytes and Epstein-Barr virus-transformed human B-cells." International journal of pharmaceutics 366, 1-2 (2009): 133-9. [PubMed Link] | [ Full text ]
  • Makhoul, F.;Kaur, P.;Johnston, TD ;Jeon, H.;Gedaly, R.;Ranjan, D. "Arteriovenous malformation of the pancreas: A case report and review of literature." The International journal of angiology : official publication of the International College of Angiology, Inc 17, 4 (2008): 211-3. [PubMed Link] |
  • McHugh, PP ;Clifford, TM ;Johnston, TD ;Banerjee, AS ;Gedaly, R.;Jeon, H.;Ranjan, D. "Seatbelt injury resulting in functional loss of a transplanted kidney." Progress in transplantation (Aliso Viejo, Calif.) 18, 3 (2008): 199-202. [PubMed Link] |
  • Gedaly, R.;Clifford, TM ;McHugh, PP ;Jeon, H.;Johnston, TD ;Ranjan, D. "Prevalent immunosuppressive strategies in liver transplantation for hepatitis C: results of a multi-center international survey." Transplant international : official journal of the European Society for Organ Transplantation 21, 9 (2008): 867-72. [PubMed Link] | [ Full text ]
  • Gedaly, R.;McHugh, PP ;Johnston, TD ;Jeon, H.;Koch, A.;Clifford, TM ;Ranjan, D. "Predictors of relapse to alcohol and illicit drugs after liver transplantation for alcoholic liver disease." Transplantation 86, 8 (2008): 1090-5. [PubMed Link] | [ Full text ]
  • McHugh, PP ;Jeon, H.;Gedaly, R.;Johnston, TD ;DePriest, PD ;Ranjan, D. "Vaginal varices with massive hemorrhage in a patient with nonalcoholic steatohepatitis and portal hypertension: Successful treatment with liver transplantation." Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 14, 10 (2008): 1538-40. [PubMed Link] | [ Full text ]
  • Jeon, H.;McHugh, PP ;Ranjan, D.;Johnston, TD ;Gedaly, R.;Pu, LL "Successful management of eviscerated renal allograft with preservation of function." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 8, 5 (2008): 1067-70. [PubMed Link] | [ Full text ]
  • Chen, C.;Jeon, H.;Johnston, TD ;Gedaly, R.;McHugh, PP ;Ranjan, D. "Cyclosporin A-induced lipid and protein oxidation in human B-cells and in Epstein-Barr virus-infected B-cells is prevented by antioxidants." Journal of investigative surgery : the official journal of the Academy of Surgical Research 21, 4 (2008): 201-8. [PubMed Link] | [ Full text ]
  • Jeon, H.;McHugh, PP ;Banerjee, A.;Gedaly, R.;Johnston, TD ;Ranjan, D. "The use of Dacron graft for cavo-cavostomy in orthotopic liver transplantation." Transplantation 85, 4 (2008): 651-3. [PubMed Link] | [ Full text ]
  • Gedaly, R.;Jeon, H.;Johnston, TD ;McHugh, PP ;Rowland, RG ;Ranjan, D. "Surgical treatment of a rare primary renal carcinoid tumor with liver metastasis." World journal of surgical oncology 6, (2008): 41. [PubMed Link] | [ Full text ]
  • McHugh, PP ;Johnston, TD ;Gedaly, R.;Jeon, H.;Ranjan, D. "Successful open pulmonary embolectomy for acute massive pulmonary embolism in a recent kidney transplant recipient." Annals of transplantation 13, 3 (2008): 19-22. [PubMed Link] | [ Full text ]
  • Clifford, TM ;Johnston, TD ;Jeon, H.;Gedaly, R.;Ranjan, D. "A pharmacoeconomic analysis of liver transplant charges." Progress in transplantation (Aliso Viejo, Calif.) 17, 4 (2007): 310-4. [PubMed Link] |
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